20+ Difference between Clotrimazole and Miconazole

Clotrimazole’s reaction time against dermatophytosis is often longer, and its reaction time against candidiasis is shorter than that of miconazole, despite miconazole’s faster reaction time against dermatophytosis and its slower reaction time against candidiasis.

Studies on dermatophytosis have indicated that miconazole has a response rate of around 75%, whereas clotrimazole has a response rate of about 56%.

Comparing clotrimazole with miconazole reveals that the former has an 80-85% response rate against candidiasis, while the latter has just a 30% response rate.

Comparison Between Clotrimazole And Miconazole

Brand nameLotrimin, the drug’s brand name, is also the name of the medication in its generic form. Clotrimazole is offered to end customers under the brand name Lotrimin. Clotrimazole is the name of the drug under which it is sold generically.Under the brand name Monistat, the pharmaceutical company that manufactures miconazole offers it for sale to end users and promotes its distribution to the market. Miconazole is also made available to the general public by the same company that distributes ketoconazole.
ReactionClotrimazole’s impact on dermatophytosis is slower but more dependable than its quick efficiency against candidiasis. This is in contrast to its rapid effectiveness against candidiasis. An overgrowth of skin fungus is the defining feature of the condition known as dermatophytosis.Miconazole is good against dermatophytosis in a short amount of time; however, it is not as effective against candidiasis and does not function as rapidly as it does against dermatophytosis.
UsageYou have the option of taking medicine orally, applying a vaginal cream to the affected area or applying the medication topically to the area that is being affected by the condition as your chosen mode of administration.Application of a lotion or ointment to the skin or the area that surrounds the entrance of the vaginal canal is one kind of treatment that falls under the category of “topical therapy.”
FormulaThe molecular structure of clotrimazole is denoted by the chemical formula C22H17CIN2, which reveals that this substance is a compound in its fundamental makeup. There is a possibility that this formula is concealed very deeply inside the molecular structure of the clotrimazole molecule.Miconazole may be represented by the chemical formula C18H24ClN20. Miconazole is a medication that fights fungal infections. Miconazole is a treatment that is helpful against a variety of fungal infections.

Major Difference Between Clotrimazole and Miconazole

What exactly is Clotrimazole?

Clotrimazole is an antifungal medication that may be used to treat a broad range of fungal infections and skin problems, such as athlete’s foot, ringworm, and candidiasis.

Lotrimin is the name of the brand that makes this medicine. Clotrimazole is a drug that may be used in various ways, including vaginally, topically, or orally.

Key Difference: Clotrimazole

  • Clotrimazole is an antifungal medication that may be used to treat various fungal infections.
  • This includes athlete’s foot, jock itch, vaginal yeast infections, oral thrush, diaper rash, and ringworm disorders, including athlete’s foot and jock itch.
  • In most instances, it takes some time for clotrimazole to be effective against dermatophytosis, although it is quite effective against candidiasis.
  • Researchers have so far uncovered 251 distinct drug interactions that involve the use of clotrimazole.

What exactly is Miconazole?

Miconazole is an antifungal medicine that is effective against various fungal diseases, including ringworm, pityriasis Versicolor, and skin and vaginal yeast infections.

This treatment is sold under the brand name Monistat. In addition, miconazole helps with the body, groin, and foot ringworm.

Miconazole may be used topically or vaginally as a cream or lotion. miconazole has the formula C18H14Cl4N2O.

This substance has a molar mass of 416.127 grams per mole. There is often a racemic mixture included. “(RS)-1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole” is the IUPAC designation for this chemical.

Key Difference: Miconazole

  • Miconazole is a powerful antifungal medicine that may treat various fungal infections.
  • Examples include ringworm, pityriasis versicolor, and vaginal and cutaneous yeast infections.
  • Miconazole, an antifungal medication, is more effective against dermatophytes, common skin diseases, than against yeast infections.
  • Two hundred eighty different drugs have been documented as having a negative interaction with miconazole.

Contrast Between Clotrimazole And Miconazole


  • Clotrimazole- Clotrimazole is available in various formulations, including soap, cream, and powder. It is also sold commercially under the brand names Lotramin and Desenex.

    This medication is made accessible in all product lines at a concentration of one percent of its active ingredient, which is the standard.
  • Miconazole- This medication is often sold in the United States at a strength of 2% and is marketed under the names Monistat vaginal cream and Zeasorb topical lotion.

    It is accessible in these forms across the country. Although the prescription could have to double the potency of clotrimazole, this does not always mean that it would work twice as rapidly.

    Miconazole may be obtained in the form of a vaginal cream as well as a topical cream.


  • Clotrimazole- Clotrimazole is an antifungal medication that can be used to treat a wide variety of fungal infections, including vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and ringworms such as athlete’s foot and jock itch, to name just a few of the conditions that fall under this category.

    Clotrimazole is also an effective treatment for yeast infections manifesting in the vaginal area.
  • Miconazole- Miconazole is an effective antifungal medicine that may be used to treat a broad range of fungal disorders, such as ringworm, pityriasis Versicolor, and skin and vaginal yeast overgrowth.

    Miconazole may also be used to treat yeast infections in the vaginal and skin areas. A prescription from a medical professional is required to purchase miconazole.

Side effects:

  • Clotrimazole- Itching and nausea were mentioned as side effects of taking medicine orally by the study participants after receiving the drug.

    On the other hand, when the chemical was administered to the participants’ skin directly, they reported that they had a burning sensation, and their skin became a bright red color.

    Participants in the clinical research who had taken medicine orally reported experiencing adverse effects of the treatment, including itching and nausea as a result of the treatment.
  • Miconazole- After the conclusion of the treatment, in addition to the itching that you were experiencing before it was provided, you may also suffer some localized pain in the area that was treated with the therapy.

    This pain will be concentrated in the region that was affected by the treatment. The location of this discomfort will be confined to the region that was treated during the procedure.

Chemical name:

  • Clotrimazole- Clotrimazole may be represented by the chemical formula C22H17ClN2, and the term Clotrimazole is the symbol for this compound.

    This treatment has a molar mass measurement of 344.84 grams per mole, which is impressive.

    The temperature at which this specific substance begins to melt is in the 147 to 149 degrees Celsius region. 1-[(2-chlorophenyl) diphenylmethyl] The IUPAC designation for this substance is 1H-imidazole, and it is often referred to by that name.
  • Miconazole- Miconazole may be represented by the chemical formula C18H14Cl4N2O. According to our calculations, this chemical’s molar mass equals 416.127 grams per mole.

    In most instances, there will also be the presence of a racemic mixture. The IUPAC designation for this substance is (RS)-1-(2-), and this is also the term that is most often used to refer to it (2,4-Dichlorobenzyloxy) -2-(2,4-chlorophenyl)ethyl) -1H-imidazole.

Frequently Asked Questions (FAQs)

Q1. How soon after taking clotrimazole do the effects of the medication start to become noticeable?

Clotrimazole is an excellent treatment for fungal infections since it can eradicate the yeast that is the primary cause of these conditions.

With this therapy, thrush may be healed in as little as a week, but the infection should be treated for at least two weeks to stop it from happening again.

Q2. What is the proper method for applying clotrimazole cream to the vaginal and rectal regions?

If you use clotrimazole cream, apply it to the area surrounding the outside of your vaginal entrance and back passage twice or thrice daily. Massage it into the skin in a gentle manner.

Keep using the lotion regularly until all of the symptoms of the infection, including the itching and the pain, have gone.

Q3. Does clotrimazole relieve the itching that you’re experiencing?

Clotrimazole medication alleviates vaginal burning, itching, and discharge, which are all symptoms that may be linked with this sickness.

This antibiotic is an antifungal azole medication for treating fungal infections. Its efficiency may be attributed to the fact that it prevents the growth of yeast (fungus), which is the root cause of the sickness.

Two distinct variants of the vaginal product may be purchased (a vaginal cream or tablet).

Q4. What are the most common problems that miconazole is used to treat?

Patients who are adults or children older than 12 years of age who have vaginal yeast infections may be treated with miconazole that has been delivered vaginally in the form of a pill.

Belongs to the group of antifungal medications known as imidazoles. This class includes other drugs like itraconazole. It does this by preventing the growth of infectious fungus inside the body.

Q5. How soon after taking miconazole do the effects of the medication start to become noticeable?

Within twenty-four hours of beginning treatment with miconazole, most people will see at least some degree of relief from their symptoms (Monistat).

After commencing therapy with miconazole (Monistat), you should start to observe some improvement within the first three days. You should be completely well by the time you reach the seventh day after starting medication.

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